Our aim is to enhance the quality of life of all children receiving cancer treatment and undergoing bone marrow transplant by accelerating the development and incorporation of evidence-based supportive care guidance into standards of care internationally.


Who we are

The international Pediatric Oncology Guidelines in supportive care (iPOG) Network is an inter-professional group with deep expertise in the supportive care of pediatric oncology patients, development of clinical practice guidelines and implementation of evidence-based care. We represent 9 local, national and international pediatric oncology organizations.


iPOG Network Core Committee members meet by teleconference monthly. Our working groups also meet by teleconference monthly. We hold an open meeting annually.


Funding is generously provided by the Garron Family Cancer Centre at The Hospital for Sick Children (SickKids), Toronto, Canada. iPOG Network activities are not directed or influenced by any funding agency.

Our vision

For the children

Working together, the iPOG Network aims to optimize the quality of life of all children receiving cancer treatment and undergoing bone marrow transplant by accelerating the development and incorporation of evidence-based supportive care into international standards of care. The iPOG Network believes that trustworthy clinical practice guidelines are the ideal tool to achieve our mission.

Our role

A trusted resource

Working with the international pediatric oncology community,
the iPOG Network:

  • Facilitates communication, collaboration, and research regarding supportive care guidance development and implementation
  • Shares best practices in clinical practice guideline development
  • Communicates evidence gaps to the pediatric oncology research community
  • Mentors clinicians in the development and implementation of trustworthy supportive care guidance for pediatric patients receiving cancer treatment
  • Builds capacity for guidance creation to address the evolving needs of pediatric patients receiving cancer treatment

Our members


SIOP logo

Our Team


We are an interprofessional group who are active in the development, endorsement or implementation of supportive care guidance.


Lee Dupuis

Lee Dupuis


Lee is an Associate Scientist, Research Institute, Health Clinician Scientist, Department of Pharmacy, and a Clinical Pharmacist, Haematology/Oncology/Blood and Marrow Transplant Program at The Hospital for Sick Children (SickKids), Toronto and Associate Professor at the Leslie Dan Faculty of Pharmacy, University of Toronto.

Lee has acted as chair for several supportive care clinical practice guideline panels and as a panel member for many others.  She is the chair of the Supportive Care Guideline sub-Committee, Children’s Oncology Group, chair of the Supportive Care Committee of the Pediatric Oncology Group of Ontario and founder and co-director of the iPOG Network.

Wim Tissing

Wim Tissing


Wim Tissing is pediatric oncologist and professor of supportive care in childhood oncology, and works in both the Princess Maxima Center for pediatric oncology in Utrecht and the University Medical Center Groningen, both in the Netherlands. In the UMCG he chairs the dept of pediatric oncology / hematology and immunology. In the Princess Máxima Center he chairs the supportive care group, which involves both patient care and research.

After his PhD in 2006 he started his translational research line on Supportive care in pediatric oncology in Groningen, and he continues this work in Utrecht. His research focuses on gastro-intestinal mucositis (UMCG) and on infections and nutrition / motion in the Princess Máxima Center. Lastly, he translates results from research into clinical practice using Clinical Practice Guidelines He (has) supervises (-ed) 24 PhD students on different projects and has published over 180 papers in international, peer reviewed journals.

He is co-chair of the IPOG network together with Lee Dupuis


Bob Philips

Bob Phillips

Lead, Methods Working Group
CCLG Representative

Bob is a Senior Clinical Academic at CRD, and an Honorary Consultant in Paediatric / Teenage-Young Adult Oncology at Leeds Children’s Hospital. His main areas of work are in the development of individual participant data (IPD) meta-analysis, supportive care management, and the development of skills in appraisal and translation of clinical research in practice. He is the lead of the PICNICC collaboration, “Predicting Infectious ComplicatioNs In Children with Cancer” which was formed by engaging international clinical and methodological experts, parent representatives and healthcare researchers to investigate primarily the patterns of risk in febrile neutropenia. The PICNICC collaboration consists of 22 different study groups from 15 countries and is actively engaged in involving new members from around the world to further develop its aims. This work develops the CRD research themes of methodological improvement in IPD meta-analysis and in improving outcomes in cancer medicine, and capacity building and translation of research in the NHS.

Bob has worked extensively to promote and teach evidence-based practice with the Centre for Evidence-based Medicine in Oxford, UK, and also the Centre for Evidence-based Child Health (Institute of Child Health, London, UK). He edits the evidence-based practice sections of the Archives of Diseases in Childhood, and is an associate editor of the journal. He has lectured in the UK, Europe, North America, Australia and the Nordic Countries on the subject of evidence-based practice, and has written widely on this.

Bob was the Clinical Lead for the NICE Guideline (CG151) on the management of neutropenic sepsis. In addition to the work in febrile neutropenia, he has undertaken many systematic reviews assessing the quality of evidence underlying interventions to ameliorate the side-effects of cancer treatments in childhood and is actively involved with developing and implementing high-quality clinical practice guidelines with the IPOG group. This includes Cochrane systematic reviews of the treatment of chemotherapy-induced nausea and vomiting, the treatment of constipation, nutritional support, and risk stratification in nephropathy. He works with the Cochrane Child Health field, the PRISMA-IPD group, and the Martin House Research Centre which encourages the development of high-quality health research with children and young people with life-limiting conditions.

Carol Digout

Carol Digout

Lead, Education Working Group
APPHON Representative

Carol is the Executive Director for the Atlantic Provincies Pediatric Hematology/Oncology Network (APPHON). Part of their mandate is to create/adopt/adapt guidelines and their implementation  for the 4 Atlantic Canadian Provinces. Carol has been involved with guidelines since starting her career in 2005. She was a member of the Cancer Care Nova Scotia Guideline Committee, C17 Guideline Committee and has been a member of the  iPOG Network for the past 3 years. Carol took a year off to work as the Atlantic Canada Guideline Coordinator for the Canadian Partnership Against Cancer and help trial the Can-Adapte. Carol’s main interest now lies in methodology, implementation and guideline adherence.

Paula Robinson

Paula Robinson

Lead, Research Working Group
POGO Representative

Paula is a Guideline Methodologist and Program Manager with the Pediatric Oncology Group of Ontario, Canada. Paula has served as a guideline methodologist on many clinical practice guideline panels as well as other committees focused on evidence-based supportive care including the Supportive Care Guideline sub-Committee, Children’s Oncology Group.


Andrea Orsey

Andrea Orsey

MASCC Representative

Andrea is a pediatric oncologist at Connecticut Children’s in Hartford, Connecticut, USA where she is the Director of the Cancer Supportive Care Services, Co-director of the Cardio-Oncology Program, Program Director of the Pediatric Hematology/Oncology Fellowship Program, and Associate Chair of Education.  Building on her background as a physical therapist, she conducts research to evaluate the impact of physical activity on quality of life, fatigue and function among pediatric oncology patients.

Andrea is the Chair of the Pediatric Study Group of MASCC which promotes and improves supportive care for pediatric cancer patients and survivors worldwide.  The Pediatric Study Group of MASCC strives to be an international leader for research, education and clinical endeavors in all aspects of supportive care for children with cancer.  

Dr Cyril Lervat

Cyril Lervat

SFCE Representative

Dr Cyril Lervat is a pediatric oncologist at Lille. He is the head of the French Pediatric Oncologic Supportive Care Committee and an active member of the French oncologic pain committee.

Joel Thompson

Joel Thompson

COG Representative

Joel is a pediatric oncologist at Children’s Mercy Hospital in Kansas City, MO (USA) and currently sits on the Children’s Oncology Group Supportive Care Guideline sub-Committee. He is interested in the implementation of clinical practice guidelines and in their use as metrics for quality improvement work in pediatric oncology.

Jessica Bate

Jessica Bate

CCLG Representative

Jessica Bate is a Consultant Paediatric Oncologist working at Southampton Children’s Hospital, UK. She is the Co-Chair of the UK Children’s Cancer and Leukaemia Group (CCLG) Supportive Care Group. She has a strong interest in supportive care research particularly preventable infections in children with cancer for which she was awarded a PhD from the University of Cambridge.
Since the COVID-19 pandemic, she has been the CCLG lead for COVID-19 guidance for professionals and families and an advisor to the UK Royal College of Paediatrics and Child Health. She is also co-leads the Vaccine Working Group for Paediatric Oncology collaboration between St Jude Chldren’s Research Hospital and SIOP (International Society of Paediatric Oncology). She is currently planning a national COVID-19 vaccine immune response study for children and young adults with cancer.
Jessica is also a member of the Paediatric Intensive Care Unit Oncology Kids in Europe Research Group (POKER) group and the National Institute of Health Research (NIHR) Cancer and Nutrition Collaborative Children and Teenage/Young Adult Workstream.

Julie Luke

Julie Luke

APHON Representative

Julie Luke is a certified pediatric nurse practitioner in San Antonio, Texas, at the Children’s Cancer and Blood Center at Methodist Children’s Hospital. She has over 29 years of experience taking care of pediatric and young adult hematology/oncology patients as both a bedside nurse and a nurse practitioner.

Lillian Sung

Lillian Sung

POGO Representative

Dr. Lillian Sung is a Professor and Senior Scientist at The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada. She is certified in the specialties of pediatrics, infectious diseases, hematology and clinical investigation. She completed a PhD in Clinical Epidemiology from the University of Toronto. She has a clinical research program focused on improving supportive care for children with cancer. Her methodological focus is on randomized and observational trials, meta-analysis, and patient-reported outcomes. She holds a Tier 1 Canada Research Chair in Pediatric Oncology Supportive Care, and she is the principal investigator on multiple operating grants from the National Institutes of Health (NIH), Canadian Cancer Society Research Institute and the Canadian Institutes of Health Research.

Marianne van de Wetering

Marianne van de Wetering

DCOG Representative

Consultant Princess Maxima Centre for pediatric oncology in Utrecht The Netherlands

She completed her pediatric training in Johannesburg South Africa. In 1995 she completed her masters project on the occurrence of infections among paediatric oncology patients in SA. Here her enthousiasm was founded to work within the supportive care field of paediatric oncology. She returned to the Netherlands in 1996 working as a consultant in the AMC/EKZ Amsterdam in the paediatric oncology unit and as from 1st June 2018 she is working as a neuro oncology consultant and supportive care and palliative care consultant at the princess MAXIMA centre of pediatric oncology in Utrecht Her thesis was completed in 2004 on infectious complications in children with cancer. National and international she is leading in supportive care in paediatric oncology with focus on infections, antiemetics and fertility. She has published papers in this field, guidelines and has many grants to do research in the field.

Dr. Rejin Kebudi picture

Rejin Kebudi

SIOP Representative

Rejin Kebudi, chair SIOP Supportive Care, is a Professor of Pediatrics and Pediatric Hematology-Oncology in the Istanbul University, Oncology Institute and Istanbul Medical Faculty. She is consultant in the American Hospital in Istanbul. She has trained in the American Collegiate Institute (Izmir), Ege University and Istanbul University. She gained international experience where she trained with scholarships: Sind Radboud Hospital, Nijmegen; New York University; Memorial Sloan Kettering Cancer Center and UCLA. She is a member of SIOP (International Society of Pediatric Oncology) since 1992, ASCO (American Society of Clinical Oncology), COG (Children’s Oncology Group, international member) and other major scientific oncology societies. She has served as the President of the Turkish Pediatric Oncology Group (TPOG) Society. She was the co-chair of the SIOP-PODC Supportive Care and Nutrition Working Group (2010-2014) and has been appointed as the chair of the SIOP Supportive Care Working Group in 2016. She received the American Society of Clinical Oncology (ASCO) International Women Who Conquer Cancer Mentorship Award in 2018. Her major work is in supportive care, cancer care in developing countries, solid tumors, sarcomas, gliomas, and retinoblastoma.


Séverine Bouttefroy

SFCE Representative

Séverine is a pédiatrician from the hematological and oncological pediatric homecare unit in Lyon, France. She is also involved in the supportive care group of the hospital (particularly for nutrition and pain) and of the French Society of Paediatric cancers (Société Française des Cancers de l’Enfant, SFCE). She joined the iPOG network in 2021

Shirley Behm

Shirley Behm

APHON Representative

Shirley Behm completed her Family Nurse Practitioner program at Bloomsburg University in Pennsylvania, the USA, and Bachelor of Science at the University of Costa Rica in Central America, Member of the APHON Global Outreach program. Member of Sigma Theta Tau International Honor Society of Nursing. She enjoys medical mission trips and serving underserved populations in the USA, Caribbean, Central, and South America. Currently employed at Geisinger Medical Center, Cancer Institute in rural Pennsylvania


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